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The fraught quest to account for sex in biology research

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Nature 609, 456-459 (2022)

doi: https://doi.org/10.1038/d41586-022-02919-x

Updates & Corrections

  • Correction 26 September 2022: This story misquoted Janine Clayton as stating that fewer than one-third of evaluated NIH-funded randomized controlled trials included two sexes. She actually said that fewer than one-third reported results by sex. The story also attributed the findings in ref. 9 to a 2020 review by Clayton and her colleagues. In fact, they were from a study published in 2019.

References

  1. Feridooni, H. A. et al. Am. J. Physiol. Heart Circ. Physiol. 312, H46–H59 (2017).

    Article  PubMed  Google Scholar 

  2. Obias-Manno, D. et al. J. Womens Health 16, 807–817 (2007).

    Article  Google Scholar 

  3. Ji, H. et al. Circulation 143, 761–763 (2021).

    Article  PubMed  Google Scholar 

  4. Doerre, A. & Doblhammer, G. PLoS ONE 17, e0268119 (2022).

    Article  PubMed  Google Scholar 

  5. Sylvester, S. V. et al. Curr. Med. Res. Opin. 38, 1391–1399 (2022).

    Article  PubMed  Google Scholar 

  6. Buch, T. et al. J. Mol. Med. 97, 871–877 (2019).

    Article  PubMed  Google Scholar 

  7. Emont, M. P. et al. Nature 603, 926–933 (2022).

    Article  PubMed  Google Scholar 

  8. Geller, S. E. et al. Acad. Med. 93, 630–635 (2018).

    Article  PubMed  Google Scholar 

  9. Feldman, S. et al. JAMA Netw. Open 2, e196700 (2019).

    Article  PubMed  Google Scholar 

  10. Woitowich, N. C., Beery, A. & Woodruff, T. eLife 9, e56344 (2020).

    Article  PubMed  Google Scholar 

  11. Garcia-Sifuentes, Y. & Maney, D. L. eLife 10, e70817 (2021).

    Article  PubMed  Google Scholar 

  12. Takahashi, T. et al. Nature 588, 315–320 (2020).

    Article  PubMed  Google Scholar 

  13. Shattuck-Heidorn, H. et al. Nature 597, E7–E9 (2021).

    Article  PubMed  Google Scholar 

  14. Peters, S. A. E. et al. BMJ Glob. Health 6, e007853 (2021).

    Article  PubMed  Google Scholar 

  15. Tamargo, J. et al. Eur. Heart J. Cardiovasc. Pharmacother. 3, 163–182 (2017).

    Article  PubMed  Google Scholar 

Download references

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