Intramolecular noncovalent interactions can block molecules in a given conformation enhancing performance of organic semiconductors. Here, the authors report a molecular descriptor to weigh them that strongly correlates with the reorganization energy of excited or charged states.

Magnetic field has been observed to promote oxygen evolution at some circumstance, however the reason for the enhancement remains unclear. Here, the authors show that enhancement is due to the disappearance of magnetic domain walls.

A bifunctional dual-atom photocatalysts with La and Ni sites is shown to be have efficient generation and transfer of photocarriers from the optically active La center to the catalytically active Ni center for promoting efficient CO₂reduction to CO.

Photoproduction of solar fuels and important chemicals is of significant interest. Here, the authors construct a cobalt single atom-based photothermal-photocatalytic heterostructure that realizes efficient hydrogen peroxide photosynthesis from earth-abundant seawater.

Chlor-alkali process plays an important role in the chemical industry. However, large overpotential and low selectivity of currently used catalysts lead to high energy consumption. Here the authors report Ru-O₄single site catalysts for chlorination evolution with 1000 h stability at 1000 mA cm⁻²in a seawater-like environment.

The authors use seismic and sedimentology data to estimate the volume of the Minoan eruption. The results show that the Plinian phase contributed most to the distal tephra fall, and that the pyroclastic flow volume is significantly smaller than previously assumed.

The authors find within-day, seasonal, and regional differences in county-level power outages from 2018–2020. Outages commonly co-occur with climate events. Counties in the south and Michigan faced high social and medical vulnerabilities and outages.

多少雨才能引发滑坡?This work shows that deep learning can identify the driving forces that can cause rainfall induced landslides, opening up the possibility of forecasting landslide events over large areas

Offshore wind power may play a key role in decarbonising energy supplies. Here the authors evaluates current grid integration capabilities for wind power in China and find that investment levels should be doubled for 2030, and that long-term storage and transmissions are key to accelerated developments of offshore wind in 2050.

The potential for enhanced sediment delivery to the Ganges-Brahmaputra delta exists, but it alone is insufficient to sustain the system. The delta may be resilient to climate change, but only in the absence of dam construction and water diversions.

TRPV1 has been associated with proliferation and survival of tumors, and can be activated by heat and other stimuli. Here, the authors block TRPV1 using photothermal nanoparticles encapsulating a TRPV1 antagonist in different cancer types, which can enhance thermo-immunotherapy in pancreatic cancer models.

Serine/threonine kinases (STKs) regulate the synthesis of capsular polysaccharide in bacteria through unclear mechanisms. Here, Tang et al. identify a protein that is phosphorylated by an STK and modulates the activity of a phosphoregulatory system inStreptococcus suis, thus linking STKs to capsular polysaccharide synthesis.

Methods to reanalyze scRNA-seq data in a spatial perspective are vital but lacking. Here, the authors develop scSpace, an integrative method that uses ST data as spatial reference to reconstruct the pseudo-space of scRNA-seq data and identify spatially variable cell subpopulations, providing insights into spatial heterogeneity from scRNA-seq data.

How cells shape signalling dynamics in MAPK cascades remains unclear. Here the authors combine mathematical modelling with in vivo validation to uncover a novel feedback mechanism that increases processivity and robustness of the yeast Hog1 module.

A complete understanding of the role of ATP hydrolysis in Hsp90 function is elusive. Here, the authors show that ATP hydrolysis, but not binding, is dispensable for essential or specialized Hsp90 functions in vivo, shedding new light on this mystery.

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

Osteoarthritis is characterized by mechanically driven pain but lacks adequate treatments. Here, the authors show that inhibiting a mechanically-sensitive ion channel expressed by nociceptors reduces pain behaviors in mouse models of joint pain.

Mechanical scratching and oxidative stress can aggravate atopic dermatitis symptoms, while treatment targeting scratching is often overlooked. Here, the authors find that enhanced phosphorylation of focal adhesion kinase is associated with scratch-exacerbated AD, then develop a hydrogel dressing that integrates oxidative stress modulation with FAK inhibition to synergistically treat AD.

The authors find within-day, seasonal, and regional differences in county-level power outages from 2018–2020. Outages commonly co-occur with climate events. Counties in the south and Michigan faced high social and medical vulnerabilities and outages.

Circulating tumor cells (CTCs) are the tumor cells responsible for metastasis. Here, the authors develop a home-built single-cell quantitative mass spectrometric platform and discover a cluster of CTCs with distinct metastatic potential using a molecular typing system based on the single-cell metabolic fingerprints.

The authors find within-day, seasonal, and regional differences in county-level power outages from 2018–2020. Outages commonly co-occur with climate events. Counties in the south and Michigan faced high social and medical vulnerabilities and outages.

Potential rooftop photovoltaic in China affords 4 billion tons of carbon mitigation in 2020 under ideal assumptions, equal to 70% of China’s carbon emissions from electricity and heat. Yet most cities have exploited the potential to a limited degree.

A rapid and large-scale reduction in car use, within a well-designed policy mix, is necessary to achieve short-term emission targets and reduce energy demand. Here, the authors introduce the Urban Transport Policy Model and demonstrate, using London as a case study, that current policies will not meet climate targets.

Mobile phone data reveals a significant decrease in the income diversity of urban encounters during the COVID-19 pandemic in the USA, even though overall mobility returned to pre-pandemic levels by late 2021. This was mainly due to persistent behavioral changes including less willingness to explore new places.

Typical cognitive tasks can produce robust experimental effects yet not measure individual differences reliably. Here the authors use hierarchical Bayesian analysis to develop and calibrate tasks that can efficiently achieve good reliability.